Examples of combining one chemotherapeutic agent with a RNA based therapy.
| RNA duplexes | Gene targets | Chemotherapeutic agent | Delivery system | BCSCs targeting strategy |
|---|---|---|---|---|
| siRNA | ABCG2, BCL2 | Doxorubicin | Niosome116 | Passive targeting |
| Clusterin, glucose-regulated protein 78 (GRP78) | Camptothecin | Liposomes67 | Passive targeting | |
| miRNA | miRNA-200c | Paclitaxel | Solid lipid nanoparticles75 | Passive targeting |
| miRNA-21 | Doxorubicin | Hollow gold nanoparticle68 | NIR-responsive | |
| shRNA | NF-κB | Doxorubicin | Mixed micelle system: carbamate-mannose modified poly(ethylenimine)117 | Passive targeting |