Table 3.

Antibiotics (dose, schedule, administration route) used in the treatment of aspiration pneumonia for patients with normal renal function (adjusted according to Mandall and Niederman 2019).

Antibiotic	Dose, Schedule, Administration route
Ampicillin–sulbactam	1.5–3 g every 6 h, intravenous
Amoxicillin–clavulanate	875 mg twice daily, oral
Piperacillin–tazobactam	4.5 g every 8 h or 3.375 g every 6 h, intravenous
Ceftriaxone	1–2 g once daily, intravenous
Cefepime	2 g every 8–12 h, intravenous
Ertapenem	1 g once daily, intravenous
Imipenem	500 mg every 6 h or 1 g every 8 h, intravenous
Meropenem	1 g every 8 h, intravenous
Levofloxacin	750 mg once daily, intravenous or oral
Moxifloxacin	400 mg once daily, intravenous or oral
Clindamycin	450 mg 3/4 times daily, oral; or 600 mg every 8 h, i.v.
Gentamicin or tobramycin †	5–7 mg/kg once daily, intravenous
Amikacin †	15 mg/kg once daily, intravenous
Colistin ‡	9 million IU per day in 2/3 divided doses, i.v.
Vancomycin †	15 mg/kg every 12 h, intravenous
Linezolid	600 mg every 12 h, intravenous or oral

^†For gentamicin and tobramycin, the dose should be adjusted to a trough level of less than 1 mg per litre, less than 4 mg per litre for amikacin, and 10 to 15 g per millilitre for vancomycin.

^‡The loading dose is 6 million to 9 million IU.