FIG. 1.
A murine chronic UTI model. C3H/HeN mice were divided into two groups. Traumatization of the bladder was performed as described in Materials and Methods for one group (●), and another group (control) (○) was mock treated with saline. E. coli strain HU-1 at a dose of 2 × 106 CFU was infused into the bladders of anesthetized mice. The counts of viable bacteria in the bladder (A) and kidneys (B) were determined on days 1, 4, 7, 10, 14, and 24 after the challenge. Results are expressed as the means and SDs for six mice. Significant differences between the untreated controls and the treated group: ∗, P < 0.05; ∗∗, P < 0.01; ∗∗∗, P < 0.001.