FIG. 4.
Effects of L. casei Shirota on histopathological changes in the urinary tract during E. coli infection. Mice were challenged intravesically with E. coli strain HU-1 at a dose of 2 × 106 CFU and were dissected for histopathological examination of the bladder 4 days later. Either saline (A and B), L. casei Shirota at a dose of 1.6 × 108 CFU (C and D), or L. fermentum ATCC 14931T at a dose of 1.0 × 108 CFU (E and F) was infused into the bladder 24 h before the challenge infection. Panels A, C, and E were stained with hematoxylin and eosin. Magnification, ×108. Panels B, D, and F were Gram stained. Magnification, ×432.