TABLE 3.
Antimicrobial activity of L. casei Shirota by daily administration during the postinfection period
| Groupa | Log10 viable E. coli organisms in bladder (mean ± SD)b
|
||
|---|---|---|---|
| Days 1–11 | Days 4–11 | Days 7–11 | |
| Control | 6.6 ± 0.9c | 4.8 ± 0.7 | 4.8 ± 0.9 |
| L. casei Shirota | 4.2c | 3.9 ± 0.7∗ | 4.3 ± 0.6 |
a
Mice were treated with saline alone (control) or L. casei Shirota (1.2 × 108 to 1.6 × 108 CFU) once daily starting on day 1, 4, or 7 and continuing to day 11.
b
Mice were infected with E. coli strain HU-1 at an inoculum of 2 × 106 CFU on day 0 and dissected on day 12 after infection. Six to eight mice per group were used. ∗, P < 0.05.
c
The incidence or infection was 8 of 8 for the control group and 2 of 7 for the L. casei Shirota-treated group, respectively (P < 0.05 by Fisher's exact probability test).