FIG. 2.

Shape descriptors reveal varying cell response. (a) Nine shape descriptors are introduced and applied to the steady-state shape of a HL60 cell [highlighted cell shape at the channel end in Fig. 1(b)]. Cell shape is represented by blue contour points and connecting line segments. (b) Time-dependent traces of deformation represented by the different shape descriptors introduced in (a) and applied to the deformed shapes of a representative HL60 cell passing a 30 × 30 μm² channel of 300 μm length at a flow rate of 8 nl s⁻¹.