TABLE 2.
Contribution of the MexAB-OprM efflux operon to antimicrobial susceptibility of P. aeruginosa biofilms
| Antibiotic | K767 (wild type)
|
K1119 (ΔmexAB-oprM)
|
OCR1 (K767 nalB; hyperexpresses mexAB-oprM)
|
|||
|---|---|---|---|---|---|---|
| MBEC (μg/ml) | MIC (μg/ml) | MBEC (μg/ml) | MIC (μg/ml) | MBEC (μg/ml) | MIC (μg/ml) | |
| Aztreonam | 1,024 | 32 | 512 | 64 | >1,024 | 32 |
| Chloramphenicol | 1,024 | 128 | 1,024 | 64 | >1,024 | 1,024 |
| Ciprofloxacin | 16 | <2 | <2 | <2 | 8 | <2 |
| Erythromycin | 1,024 | 32 | 1,024 | 8 | >1,024 | 256 |
| Gentamicin | 16 | 4 | 4 | <2 | 32 | 4 |
| Piperacillin | 1,024 | 32 | 1,024 | 32 | >1,024 | 128 |
| Tetracycline | 512 | 64 | 128 | 64 | >1,024 | 256 |
| Tobramycin | 64 | <2 | 16 | <2 | 512 | <2 |