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. 2022 Mar 29;322(6):R467–R485. doi: 10.1152/ajpregu.00017.2022

Figure 4.

Figure 4.

Endocrine signals and renal function effects of diet and DOCA-salt. A: urine aldosterone elimination rate per day: two-way ANOVA diet P < 0.01, DOCA P < 0.01, diet × DOCA P = 0.05. B: urine copeptin elimination rate per day: two-way ANOVA diet P = 0.02, DOCA P < 0.01, diet × DOCA P = 0.07. C: urine aquaporin-2 shedding rate per day: two-way ANOVA diet P < 0.01, DOCA P < 0.01, diet × DOCA P < 0.01. D: regression modeling of relationship between urine osmolality vs. urine copeptin elimination rate: slopes P < 0.01 vs. slope of zero, and comparison of slopes P = 0.49. E: regression modeling of relationship between urine aquaporin-2 shedding rate vs. urine copeptin elimination rate: slopes are all P < 0.05 vs. slope of zero, and comparison of slopes P < 0.01. F: plasma Na concentration: two-way ANOVA diet P = 0.03, DOCA P < 0.01, diet × DOCA P = 0.22. For AF, n = 8 for all groups except n = 7 for 5L0D + sham and 7913 + sham. For AF, summary data are presented as means ± SE, and *P < 0.05 by Tukey’s multiple comparisons procedure. DOCA, deoxycorticosterone acetate.