Table 1.

Tissue masses after 3 wk of DOCA-salt or sham treatment

End Point	5L0D (n = 8, 8)	2920x (n = 8, 8)	7913 (n = 8, 8)	P Value
				Diet	DOCA	Diet × DOCA
Body mass, g
Sham	25.9 ± 0.3	26.3 ± 0.5	24.6 ± 0.4	<0.01	0.52	<0.01
DOCA-salt	24.2 ± 0.3	26.2 ± 0.5	25.8 ± 0.4
Interscapular fat, mg
Sham	63 ± 8	83 ± 19	61 ± 3	0.15	0.07	0.11
DOCA-salt	67 ± 6	85 ± 5 b	99 ± 7a,b
Perigonadal fat, mg
Sham	232 ± 27	376 ± 53	331 ± 19	<0.01	<0.01	0.45
DOCA-salt	330 ± 24	525 ± 50b	523 ± 28
Perirenal fat, mg
Sham	50 ± 2	93 ± 14	76 ± 9	<0.01	<0.01	0.97
DOCA-salt	85 ± 9	129 ± 13	116 ± 6
Inguinal fat, mg
Sham	151 ± 30	184 ± 29	142 ± 9	0.12	<0.01	0.08
DOCA-salt	167 ± 12	209 ± 14	237 ± 11a
Liver, g
Sham	1.05 ± 0.12	1.10 ± 0.08	1.12 ± 0.03	<0.01	<0.01	0.03
DOCA-salt	1.27 ± 0.13	1.79 ± 0.08a,b	1.70 ± 0.03a,b
Heart ventricles, mg
Sham	106 ± 4	116 ± 3	94 ± 3c	<0.01	0.59	<0.01
DOCA-salt	103 ± 2	106 ± 2	103 ± 4
Adrenal glands, mg
Sham	4.2 ± 0.3	3.3 ± 0.3	2.8 ± 0.5	0.04	0.11	0.41
DOCA-salt	2.9 ± 0.6	2.6 ± 0.4	2.6 ± 0.2
Kidneys, mg
Sham	335 ± 8	335 ± 7	300 ± 9	0.14	<0.01	0.04
DOCA-salt	415 ± 11a	436 ± 10a,b	432 ± 11 a
Spleen, mg
Sham	61 ± 3	69 ± 5	57 ± 3	<0.01	<0.01	0.09
DOCA-salt	45 ± 1a	59 ± 2b	55 ± 2
Tibia, cm
Sham	1.91 ± 0.06	1.88 ± 0.05	1.79 ± 0.04	0.85	0.12	0.18
DOCA-salt	1.80 ± 0.07	1.96 ± 0.04	1.84 ± 0.05

Data are presented as means ± SE. Data analyzed by two-way repeated-measures ANOVA. ^aP < 0.05 vs. diet-matched sham, ^bP < 0.05 vs. 5L0D + DOCA, and ^cP < 0.05 vs. 2920-sham by Tukey’s multiple comparison procedure. DOCA, deoxycorticosterone acetate.