Table 10.
Ventilatory function as assessed by plethysmography
| End Point | Sham 2920x (n = 10) |
DOCA 2920x (n = 9) |
Sham 5L0D (n = 10) |
DOCA 5L0D (n = 10) |
P Value |
||
|---|---|---|---|---|---|---|---|
| Diet | DOCA | Diet × DOCA | |||||
| Room air | |||||||
| V̇e, mL/100 g/min | 87.1 ± 5.6 | 91.6 ± 4.9 | 90.5 ± 4.1 | 89.3 ± 4.6 | 0.91 | 0.74 | 0.56 |
| VT, mL/breath/100 g | 0.48 ± 0.03 | 0.47 ± 0.02 | 0.43 ± 0.02 | 0.46 ± 0.02 | 0.24 | 0.57 | 0.34 |
| Frequency, breath/min | 185 ± 4 | 196 ± 8 | 210 ± 6 | 192 ± 8 | 0.14 | 0.65 | 0.03 |
| Hypoxia | |||||||
| V̇e, mL/100 g/min | 128.4 ± 11.5 | 135.5 ± 7.6 | 133.0 ± 7.8 | 116.0 ± 8.0 | 0.41 | 0.58 | 0.19 |
| (% of room air) | 142 ± 8 | 140 ± 10 | 138 ± 9 | 127 ± 13 | 0.41 | 0.58 | 0.68 |
| VT, mL/breath/100 g | 0.51 ± 0.04 | 0.55 ± 0.02 | 0.53 ± 0.02 | 0.51 ± 0.02 | 0.71 | 0.79 | 0.31 |
| (% of room air) | 114 ± 6 | 115 ± 5 | 118 ± 5 | 111 ± 7 | 0.99 | 0.59 | 0.49 |
| Frequency, breath/min | 250 ± 10 | 247 ± 9 | 248 ± 7 | 229 ± 11 | 0.29 | 0.23 | 0.40 |
| (% of room air) | 125 ± 5 | 120 ± 4 | 116 ± 5 | 115 ± 6 | 0.22 | 0.50 | 0.64 |
| Hypercapnia | |||||||
| V̇e, mL/100 g/min | 283.6 ± 27.7 | 268.7 ± 13.7 | 256.1 ± 21.2 | 244.6 ± 14.1 | 0.21 | 0.52 | 0.93 |
| (% of room air) | 341 ± 15 | 312 ± 13 | 317 ± 18 | 311 ± 12 | 0.42 | 0.24 | 0.46 |
| VT, mL/breath/100 g | 0.83 ± 0.08 | 0.80 ± 0.04 | 0.74 ± 0.06 | 0.75 ± 0.03 | 0.22 | 0.91 | 0.71 |
| (% of room air) | 170 ± 7 | 178 ± 9 | 184 ± 6 | 171 ± 9 | 0.65 | 0.79 | 0.17 |
| Frequency, breath/min | 342 ± 7 | 336 ± 9 | 345 ± 3 | 323 ± 8 | 0.47 | 0.06 | 0.29 |
| (% of room air) | 200 ± 3 | 185 ± 10 | 172 ± 8 | 182 ± 6 | 0.03 | 0.76 | 0.08 |
Data presented as means ± SE and analyzed via two-way ANOVA. DOCA, deoxycorticosterone acetate; V̇e, minute ventilation; VT, tidal volume.