Table 3.
Metabolic parameters assessed via Promethion multiplexed phenotyping system, body composition changes assessed by NMR, estimates of calories committed to growth, and total unaccounted calories (hypothesized to be a metric of anaerobic energy expenditure)
| End Point | 5L0D + DOCA (n = 9) |
2920x + DOCA (n = 9) |
P Value |
||
|---|---|---|---|---|---|
| FFM | Fat | Diet | |||
| Body mass, g | |||||
| (uncorrected) | 25.35 ± 0.56 | 26.39 ± 0.78 | 0.30 | ||
| Fat-free mass (FFM), g | |||||
| (uncorrected) | 19.22 ± 0.44 | 19.40 ± 0.47 | 0.79 | ||
| Fat mass, g | |||||
| (uncorrected) | 5.86 ± 0.11 | 6.01 ± 0.25 | 0.59 | ||
| Light phase heat, kcal/h | |||||
| (uncorrected) | 0.394 ± 0.009 | 0.374 ± 0.012 | 0.19 | ||
| (EMM) | 0.395 ± 0.007 | 0.372 ± 0.007 | <0.01 | 1.00 | 0.04 |
| Dark phase heat, kcal/h | |||||
| (uncorrected) | 0.479 ± 0.011 | 0.0472 ± 0.014 | 0.69 | ||
| (EMM) | 0.480 ± 0.011 | 0.471 ± 0.011 | 0.01 | 0.85 | 0.53 |
| Locomotor activity, m/d | |||||
| (uncorrected) | 374.25 ± 30.17 | 342.46 ± 33.94 | 0.49 | ||
| (EMM) | 371.21 ± 29.05 | 345.50 ± 29.05 | 0.10 | 0.07 | 0.54 |
| Food intake, g/d | |||||
| (uncorrected) | 4.94 ± 0.33 | 3.65 ± 0.23 | 0.01 | ||
| (EMM) | 4.96 ± 0.28 | 3.62 ± 0.28 | 0.14 | 0.96 | <0.01 |
| Meals per phase, n | |||||
| Light phase | 25.6 ± 3.0 | 23.6 ± 3.0 | |||
| Dark phase | 39.9 ± 1.5 | 34.3 ± 3.1 | |||
| Total fluid intake, mL/d | |||||
| (uncorrected) | 18.50 ± 1.21 | 9.80 ± 1.56 | <0.01 | ||
| (EMM) | 18.46 ± 1.26 | 9.85 ± 1.26 | 0.04 | 0.16 | <0.01 |
| Total Na intake, mEq/d | |||||
| (uncorrected) | 1.28 ± 0.14 | 0.67 ± 0.13 | 0.01 | ||
| (EMM) | 1.30 ± 0.13 | 0.65 ± 0.13 | 0.08 | 0.79 | <0.01 |
| Δ Fat mass, Mon–Fri | |||||
| (grams) | −0.57 ± 0.12 | −1.05 ± 0.13 | 0.01 | ||
| (kcal equivalent @ 9 kcal/g) | −5.15 ± 1.10 | −9.43 ± 1.13 | |||
| Δ Fat-free mass, Mon–Fri | |||||
| (grams) | 0.24 ± 0.10 | 0.08 ± 0.11 | 0.28 | ||
| (kcal equivalent @ 4 kcal/g) | 2.18 ± 0.87 | 0.75 ± 0.95 | |||
| Calories to growth, Mon–Fri | |||||
| (kcal) | −4.18 ± 1.21 | −9.10 ± 1.17 | 0.01 | ||
| Calories consumed, Mon–Fri | |||||
| (kcal) | 160.71 ± 9.84 | 69.85 ± 8.48 | <0.01 | ||
| Calories absorbed, Mon–Fri | |||||
| (digestive efficiency from Fig. 2D; %) | 81.0 ± 0.8 | 86.6 ± 0.8 | <0.01 | ||
| (kcal) | 130.18 ± 7.97 | 60.49 ± 7.35 | <0.01 | ||
| Total aerobic expenditure, Mon–Fri | |||||
| (kcal) | 40.38 ± 0.96 | 39.07 ± 1.08 | 0.38 | ||
| Unaccounted energy, Mon–Fri | |||||
| (kcal) | 93.97 ± 7.58 | 30.53 ± 7.03 | <0.01 | ||
| (% intake) | 72 ± 2 | 38 ± 14 | 0.03 | ||
Data presented as means ± SE. Data analyzed by t test when uncorrected for covariates, or by GLM when correcting for fat-free mass (FFM) and fat mass. Estimated marginal means (EMM) ± SE values are reported after consideration of covariates at FFM = 19.31 g, fat mass = 5.93 g. DOCA, deoxycorticosterone acetate. GLM, generalized linear model.