. 2022 Mar 29;322(6):R467–R485. doi: 10.1152/ajpregu.00017.2022

Table 5.

Urinalyses after 3 wk of DOCA-salt or sham treatment

End Point	5L0D (n = 8, 8)	2920x (n = 8, 8)	7913 (n = 8, 8)	P Value
End Point	5L0D (n = 8, 8)	2920x (n = 8, 8)	7913 (n = 8, 8)	Diet	DOCA	Diet × DOCA
Urine creatinine, mg/mL
Sham	0.65 ± 0.07	0.50 ± 0.06^a	0.79 ± 0.09	0.01	<0.01	0.04
DOCA-salt	0.08 ± 0.01^b	0.06 ± 0.01^b	0.08 ± 0.01^b
Urine osmolytes, mOsmol/kgH₂O/d
Sham	5.8 ± 0.2^a	4.2 ± 0.3	3.6 ± 0.2	<0.01	<0.01	0.61
DOCA-salt	7.3 ± 0.8	4.8 ± 0.4^c	4.8 ± 0.1^c
Potential renal solute load, mOsmol/kgH₂O/d
Sham	8.43 ± 1.70	6.40 ± 0.54^d	7.42 ± 0.45	<0.01	0.43	0.08
DOCA-salt	9.60 ± 0.84	6.13 ± 1.23^c	7.21 ± 0.61^c
Potential renal solute load, minus urine osmolytes, mOsmol/kgH₂O/d
Sham	2.65 ± 1.90	2.21 ± 0.44	3.78 ± 0.78	0.01	0.01	0.45
DOCA-salt	2.33 ± 1.87	1.30 ± 0.73	2.38 ± 0.51
Urine protein, mg/mL
Sham	38.7 ± 2.0^a	49.2 ± 4.4	54.3 ± 5.4	0.04	<0.01	0.04
DOCA-salt	3.2 ± 0.3^b	3.8 ± 0.3^b	3.3 ± 0.2^b
Urine protein, mg/d
Sham	69.3 ± 1.9	54.7 ± 4.0	47.5 ± 2.9	<0.01	0.30	0.96
DOCA-salt	65.5 ± 7.3	50.5 ± 2.5	45.4 ± 1.8^c
Urine Na, mEq/L
Sham	0.27 ± 0.01	0.16 ± 0.01^a,d	0.26 ± 0.02	<0.01	<0.01	<0.01
DOCA-salt	0.04 ± 0.01^b	0.06 ± 0.01^b	0.07 ± 0.01^b
UNOx, μmol/L
Sham	211 ± 21^a	245 ± 58^a	443 ± 31	<0.01	<0.01	<0.01
DOCA-salt	1 ± 0^b	1 ± 0^b	1 ± 0^b
UNOx, mmol/d
Sham	0.37 ± 0.02^a,d	0.25 ± 0.03^a	0.41 ± 0.04	<0.01	<0.01	<0.01
DOCA-salt	0.03 ± 0.01^b	0.01 ± 0.01^b	0.01 ± 0.00^b

Data presented as means ± SE and analyzed by two-way ANOVA. ^aP < 0.05 vs. 7913-sham, ^bP < 0.05 vs. diet-matched sham, ^cP < 0.05 vs. 5L0D-DOCA, ^dP < 0.05 vs. 5L0D-sham by Tukey’s multiple comparison procedure. DOCA, deoxycorticosterone acetate.