Table 7.
Blood chemistries after 3 wk of DOCA-salt or sham treatment
| End Point | 5L0D (n = 8, 8) |
2920x (n = 8, 8) |
7913 (n = 8, 8) |
P Value |
||
|---|---|---|---|---|---|---|
| Diet | DOCA | Diet × DOCA | ||||
| Plasma Na, mmol/L | ||||||
| Sham | 146.1 ± 0.6 | 146.5 ± 0.6 | 144.6 ± 0.8 | 0.03 | <0.01 | 0.22 |
| DOCA-salt | 149.1 ± 0.6a | 151.3 ± 0.8a | 149.8 ± 0.5a | |||
| Plasma K, mmol/L | ||||||
| Sham | 6.4 ± 0.2 | 6.2 ± 0.2 | 6.1 ± 0.1 | <0.01 | <0.01 | 0.08 |
| DOCA-salt | 4.0 ± 0.1a | 3.1 ± 0.1a,b | 3.2 ± 0.0a,b | |||
| Plasma Cl, mmol/L | ||||||
| Sham | 115.9 ± 1.0 | 117.3 ± 1.1 | 117.9 ± 1.1 | 0.09 | <0.01 | <0.01 |
| DOCA-salt | 108.1 ± 1.2a | 103.9 ± 1.7a | 100.6 ± 0.8a,b | |||
| Plasma iCa, mmol/L | ||||||
| Sham | 0.99 ± 0.06 | 1.06 ± 0.05 | 0.87 ± 0.07 | 0.09 | 0.74 | 0.06 |
| DOCA-salt | 0.90 ± 0.05 | 1.03 ± 0.04 | 1.02 ± 0.04 | |||
| Blood glucose, mg/dL | ||||||
| Sham | 157 ± 5 | 182 ± 9 | 162 ± 8 | 0.08 | 0.06 | 0.48 |
| DOCA-salt | 145 ± 7 | 158 ± 13 | 158 ± 4 | |||
| BUN, mg/dL | ||||||
| Sham | 32.3 ± 1.1 | 21.4 ± 1.0c | 22.6 ± 0.9c | <0.01 | <0.01 | <0.01 |
| DOCA-salt | 14.0 ± 1.0a | 9.3 ± 0.6a,b | 8.5 ± 0.6a,b | |||
| Hematocrit, %PCV | ||||||
| Sham | 44.3 ± 0.9 | 46.6 ± 0.8 | 44.0 ± 0.5 | 0.01 | 0.03 | 0.56 |
| DOCA-salt | 43.8 ± 1.0 | 44.5 ± 0.7 | 42.5 ± 0.3 | |||
| Total CO2, mmol/L | ||||||
| Sham | 22.4 ± 0.5 | 19.6 ± 1.2 | 22.3 ± 1.4 | <0.01 | <0.01 | <0.01 |
| DOCA-salt | 29.0 ± 0.8a | 30.0 ± 1.3a,d | 36.5 ± 1.0a,b,d | |||
| Anion gap, mmol/L | ||||||
| Sham | 15.1 ± 0.9 | 17.0 ± 1.3 | 11.4 ± 1.5e | <0.01 | <0.01 | 0.32 |
| DOCA-salt | 17.0 ± 1.0 | 20.7 ± 1.6 | 17.0 ± 0.9a | |||
Data presented as means ± SE and analyzed by two-way repeated measures ANOVA. aP < 0.05 vs. diet-matched sham, bP < 0.05 vs. 5L0D + DOCA, cP < 0.05 vs. 5L0D + sham, dP < 0.05 vs. 2920 + DOCA, eP < 0.05 vs. 2920 + sham by Tukey’s multiple-comparisons procedure. DOCA, deoxycorticosterone acetate; PCV, packed cell volume.