Figure 5.

Deriving “Consensus Clusters” of cytokines that consistently demonstrate comodulation patterns across regions of the respiratory tract commonly evaluated in clinical and toxicological research. Venn diagrams are used here to compare which cytokines clustered together across each respiratory compartment, yielding Consensus Cluster A, including cytokines involved in host defense (A); Consensus Cluster B, including cytokines involved in chemotactic immune cell recruitment (B); and Consensus Cluster C, including cytokines involved in immune cell adhesion and inflammation (C). NELF, nasal epithelial lining fluid; NLF, nasal lavage fluid.