Figure 6.

Individual cytokine expression levels (A) and eigencytokine values (B) describing cluster-level trends for the derived Consensus Clusters across all subjects. Subjects were ordered first according to tobacco use status, starting with nonsmokers (NS) then cigarette smokers (CS) and e-cigarette users (Ecig). Within tobacco use groups, subjects are ordered from lowest to highest average cytokine concentration (or eigenvector value) from left to right. Within each cluster, cytokines are ordered from lowest to highest average cytokine concentration from bottom to top. This figure depicts minimal changes occurring at the individual cytokine level (A) and much more robust changes occurring at the cytokine cluster level associated with tobacco use (B), particularly in e-cigarette users compared with nonsmokers.