Table 5.
Biological pathways that are associated with the Consensus Clusters identified throughout the respiratory samples (Consensus Clusters A–C)
| Pathway | P Value |
|---|---|
| (A) Consensus Cluster A | |
| Role of pattern recognition receptors in recognition of bacteria and viruses | 7.9E-14 |
| Role of cytokines in mediating communication between immune cells | 4.0E-13 |
| T helper cell differentiation | 1.6E-12 |
| Systemic lupus erythematosus in B-cell signaling pathway | 3.2E-12 |
| Altered T-cell and B-cell signaling in rheumatoid arthritis | 5.0E-12 |
| (B) Consensus Cluster B | |
| Granulocyte adhesion and diapedesis | 1.6E-11 |
| IL17 signaling | 2.5E-11 |
| Agranulocyte adhesion and diapedesis | 2.5E-11 |
| Differential regulation of cytokine production in macrophages and T helper cells by IL17A and IL17F | 3.2E-11 |
| Role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza | 2.3E-08 |
| (C) Consensus Cluster C | |
| Granulocyte adhesion and diapedesis | 3.2E-09 |
| Agranulocyte adhesion and diapedesis | 5.0E-09 |
| Pathogenesis of multiple sclerosis | 8.3E-07 |
| IL17A signaling in gastric cells | 7.4E-06 |
| Neuroinflammation signaling pathway | 8.9E-06 |
The top five most significantly associated canonical pathways associated with each cluster are listed.