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. 2022 Apr 22;2022:9629158. doi: 10.1155/2022/9629158

Figure 2.

Figure 2

MiR-375-3p inhibitor and ferrostatin-1 alleviate cardiac fibrosis in an I/R rat model. (a) The coronary artery stenosis of rats in the sham operation group (sham), I/R group, miRNA NC inhibitor treatment group, miR-375-3p inhibitor treatment group and Fer-1 treatment group was monitored by coronary artery imaging. (b) Quantitative analysis of the degree of coronary artery infarction in each group of rats. (c) Echocardiographic examination of rats in each treatment group. (d) Quantitative assessment of LVEF, LVFS, LVIDs and LVIDd of rats in each treatment group. (e) HE and Masson staining of myocardial tissue of rats in each treatment group. (f) Levels of MDA, SOD, iron ion and ROS in the myocardial tissue of rats in each treatment group. Note.∗P < 0.05 vs. sham, ∗∗P < 0.01 vs. sham, ##P < 0.01 vs. I/R and NC antagomir.