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. 2022 Feb 14;2022:8035109. doi: 10.1155/2022/8035109

Figure 4.

Figure 4

NAC treatment ameliorates mechanical allodynia of CPIP rats. (a) Schematic protocol showing time points for model establishment and NAC/vehicle treatment. (b) Time course of 50% PWT changes after NAC/vehicle treatment. The CPIP+NAC group receives daily NAC (200 mg/kg, i.p.) treatment, whereas the CPIP+Veh group receives vehicle (PBS, i.p.) treatment. (c) Summary of AUC as in (b). (d) Ipsilateral SCDH with c-Fos staining from the control+Veh, CPIP+Veh, and CPIP+NAC groups. (e) Summary of the number of c-Fos-positive cells per observation field. (f) Ipsilateral SCDH with GFAP staining. Summary of the normalized fluorescence intensity (%) of GFAP (g) and percentage of GFAP-stained area (h). (i) Ipsilateral SCDH with OX42 staining. Summary of the normalized fluorescence intensity (%) of OX42 (j) and percentage of OX42-stained area (k). Scale bar = 100 μm. n = 5‐6 rats/group. ∗p < 0.05 and ∗∗p < 0.01 vs. the control+Veh group. #p < 0.05 and ##p < 0.01 vs. the CPIP+Veh group.