Cytotoxicity and antiviral activity of UA and its synthetic derivatives against PRRSV GD-XH strain in MARC-145 cellsa.
| Compound | bCC50 (μM) | cEC50 (μM) | dSelectivity index (SI) |
|---|---|---|---|
| 1 | 29.0 ± 1.8 | 3.51 ± 0.42 | 8.3 |
| 2 | 36.5 ± 2.1 | 8.98 ± 0.55 | 4.1 |
| 3 | 81.3 ± 3.9 | 6.21 ± 0.47 | 13 |
| 4 | 41.6 ± 2.7 | 5.29 ± 0.31 | 7.9 |
| 5 | 81.4 ± 3.3 | 5.02 ± 0.37 | 16 |
| 6 | >160 | 28.3 ± 1.9 | >5.7 |
| 7 | 109 ± 5.6 | 4.01 ± 0.29 | 27 |
| 8 | >160 | 3.89 ± 0.33 | >41 |
| 9 | >160 | 2.03 ± 0.25 | >79 |
| 10 | >160 | 12.1 ± 0.94 | 13 |
| 11 | 88.3 ± 4.1 | 3.18 ± 0.39 | 28 |
| 12 | >160 | 3.88 ± 0.40 | >41 |
| 13 | >160 | 5.91 ± 0.44 | >27 |
| 14 | >160 | 4.89 ± 0.50 | >33 |
| 15 | >160 | 33.5 ± 2.6 | >4.8 |
| UA | 65.3 ± 3.2 | 8.03 ± 0.93 | 8.1 |
| Ribavirin | >640 | 23.7 ± 3.1 | >27 |
a
UA, ursolic acid.
b
CC50, the 50% cytotoxic concentrations of compounds on MARC-145 cells.
c
EC50, the 50% effective concentrations for keeping cells from PRRSV infection.
d
SI (selectivity index) is the ratio of CC50 to EC50. Data are presented as means ± SD of results from three independent experiments.