Inhibition of representative five compounds on the replication of three different PRRSV strains in MARC-145 cells.
Compound | CH-1a | VR2332 | NADC30-like | |||
---|---|---|---|---|---|---|
EC50 (μM) | SI | EC50 (μM) | SI | EC50 (μM) | SI | |
8 | 6.02 ± 0.46 | >27 | 2.47 ± 0.31 | >65 | 2.03 ± 0.25 | >79 |
9 | 3.89 ± 0.30 | >41 | 1.30 ± 0.22 | >123 | 1.28 ± 0.18 | >125 |
12 | 4.38 ± 0.37 | >36 | 1.56 ± 0.20 | >102 | 1.28 ± 0.16 | >125 |
14 | 15.7 ± 1.1 | >10 | 4.02 ± 0.36 | >40 | 3.73 ± 0.28 | >43 |
UA | 11.3 ± 0.78 | 5.8 | 5.66 ± 0.52 | 11 | 5.03 ± 0.35 | 13 |
Ribavirin | 31.5 ± 2.8 | >20 | 22.3 ± 3.1 | >29 | 16.8 ± 2.1 | >38 |