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. 2020 Jun 15;10(38):22783–22796. doi: 10.1039/d0ra04070c

Inhibition of representative five compounds on the replication of three different PRRSV strains in MARC-145 cells.

Compound CH-1a VR2332 NADC30-like
EC50 (μM) SI EC50 (μM) SI EC50 (μM) SI
8 6.02 ± 0.46 >27 2.47 ± 0.31 >65 2.03 ± 0.25 >79
9 3.89 ± 0.30 >41 1.30 ± 0.22 >123 1.28 ± 0.18 >125
12 4.38 ± 0.37 >36 1.56 ± 0.20 >102 1.28 ± 0.16 >125
14 15.7 ± 1.1 >10 4.02 ± 0.36 >40 3.73 ± 0.28 >43
UA 11.3 ± 0.78 5.8 5.66 ± 0.52 11 5.03 ± 0.35 13
Ribavirin 31.5 ± 2.8 >20 22.3 ± 3.1 >29 16.8 ± 2.1 >38