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. 2022 Mar 30;41(18):2638–2650. doi: 10.1038/s41388-022-02279-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A BIX10294 impaired the capacity for vasculogenic mimicry (VM) in pre-treated HUVEC and MUM 2B cell lines. B The expression levels of VM biomarker genes were inhibited by BIX10294 in pre-treated HUVEC and MUM 2B cell lines. C Pharmacological inhibition of G9a impaired the ability of VM in pretreated CADO-ES and RM82 cell lines. D The levels of expression of VM biomarker genes were partially inhibited by BIX10294 in pre-treated EWS cell lines. The number of tubes formed during VM progress was reduced in (E) pre-treated HUVEC and MUM 2B cell lines, and in (F) pre-treated CADO-ES and RM82 cell lines. *p < 0.05; **p < 0.01; ***p < 0.001.