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. 2021 Nov 8;27(2):849–854. doi: 10.1038/s41380-021-01376-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — SCZ_S1 (SCHEMA1, risk-genes with p < 10⁻⁴), SCZ_S2 (SCHEMA2, risk-genes with p < 10⁻³), SCZ_G1 (GWAS1, FINEMAP prioritized genes), SCZ_G2 (GWAS2, all prioritized genes). A The numbers of the GC-boxes in the proximal promoter region (−140,−41) of the GC-box containing genes were boxplotted in different groups of genes. Permutation tests showed no significant difference between the EPD group and any of the disease groups. B The GC content in the proximal promoter region (−140,−41) was calculated for each gene. Welch’s t tests were used for statistical analysis (Supplemental Table S4). All of the risk-gene groups except SCZ_G1 (black) have a significantly higher GC content than the EPD group after FDR correction of multiple comparisons.