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. 2021 Nov 5;27(2):929–938. doi: 10.1038/s41380-021-01318-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Representative images (a) and box-and-whisker plots (b) of O4-positive (red) oligodendrocytes among all DAPI-positive (blue) cells in culture are shown. Since the assumption of normality was not met (Shapiro–Wilk tests: +/+, W(35) = 0.888, p = 0.002; +/−, W(19) = 0.898, p = 0.045), we applied a generalized linear mixed model of log-transformed data. Progenitor cells derived from the lateral ventricular walls of P21 Tbx1 +/− mice produced consistently fewer O4-positive oligodendrocytes than those of +/+ mice across the cultures (Genotype, F(1,11.451) = 12.841. p = 0.004, *** Image field, F(3, 33.978) = 0.609, p = 0.614; Genotype x Image field, F(3,33.978) = 0.134, p = 0.939). Scale bar = 200 μm. +/+, n = 9; +/−, n = 5.