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. 2021 Nov 5;27(2):929–938. doi: 10.1038/s41380-021-01318-4

Fig. 6. Attentional set shifting.

Fig. 6

Box-and-whisker plots of (a) the number of trials required to reach the criterion (i.e., eight consecutive correct choices) and (b) latency to complete each trial during the first five correct choices. Since the normality assumption was violated (a, p = 0.002, at IDS-IV of +/−; b, p = 0.001, at IDS-IV rev of +/+), we analyzed both sets of data using a generalized linear mixed model. There was no between-genotype difference in the number of trials taken to reach the criterion (Genotype, F(1,16) = 1.965, p = 0.180; Genotype × Phase, F(7,112) = 0.824, p = 0.569). SD simple discrimination, CD compound discrimination, IDS intradimensional shift, rev reversal, EDS extradimensional shift. +/− mice were consistently slow in completing this task in a phase-dependent manner (Genotype, F(1,16) = 10.010, p = 0.006; Genotype × Phase, F(7, 112) = 2.566, p = 0.017). Mann–Whitney nonparametric post hoc comparisons revealed a significant between-genotype difference in latency to completing the two phases of SD (**, p < 0.01) and IDS-IV rev (*, p < 0.05). +/+ = 11, +/− = 7.