Table 1.
Head-to-head comparisons for response to treatment (left lower half) and all-cause discontinuation (right upper half).
| ARI | 0.841 (0.628, 1.127) | 0.749 (0.494, 1.136) | 0.993 (0.729, 1.352) | 0.834 (0.609, 1.142) | 0.316 (0.014, 7.087) | 0.340 (0.034, 3.387) | 1.035 (0.508, 2.107) | 0.948 (0.767, 1.172) | 0.754 (0.533, 1.067) | 0.715 (0.450, 1.136) | 0.816 (0.659, 1.009) | 1.297 (1.046, 1.609) | 1.103 (0.779, 1.562) | 1.106 (0.829, 1.477) | 1.074 (0.809, 1.425) | 1.100 (0.515, 2.347) | 0.629 (0.467, 0.847) | 0.479 (0.262, 0.876) | 0.989 (0.791, 1.237) | 0.544 (0.286, 1.035) | 0.970 (0.735, 1.282) | 0.840 (0.719, 0.980) | |
| 1.194 (0.938, 1.519) | ASE | 0.890 (0.561, 1.411) | 1.180 (0.818, 1.704) | 0.991 (0.684, 1.436) | 0.376 (0.017, 8.486) | 0.405 (0.040, 4.056) | 1.230 (0.588, 2.572) | 1.127 (0.834, 1.522) | 0.897 (0.600, 1.339) | 0.850 (0.514, 1.406) | 0.969 (0.720, 1.306) | 1.542 (1.183, 2.010) | 1.311 (0.879, 1.956) | 1.315 (0.926, 1.868) | 1.276 (0.905, 1.800) | 1.307 (0.597, 2.861) | 0.747 (0.522, 1.070) | 0.570 (0.302, 1.074) | 1.176 (0.878, 1.575) | 0.646 (0.330, 1.267) | 1.154 (0.819, 1.626) | 0.998 (0.777, 1.282) | |
| BRE | 1.326 (0.828, 2.125) | 1.114 (0.693, 1.789) | 0.422 (0.018, 9.675) | 0.455 (0.044, 4.649) | 1.382 (0.624, 3.059) | 1.266 (0.827, 1.938) | 1.007 (0.612, 1.659) | 0.955 (0.533, 1.711) | 1.089 (0.715, 1.660) | 1.733 (1.141, 2.632) | 1.473 (0.896, 2.422) | 1.478 (0.934, 2.339) | 1.434 (0.908, 2.267) | 1.469 (0.636, 3.392) | 0.840 (0.528, 1.337) | 0.640 (0.318, 1.290) | 1.321 (0.867, 2.012) | 0.726 (0.348, 1.514) | 1.296 (0.824, 2.040) | 1.121 (0.762, 1.651) | |||
| 0.804 (0.577, 1.119) | 0.673 (0.470, 0.964) | CARB | 0.840 (0.572, 1.233) | 0.318 (0.014, 7.205) | 0.343 (0.034, 3.445) | 1.042 (0.495, 2.194) | 0.955 (0.692, 1.317) | 0.760 (0.505, 1.143) | 0.720 (0.431, 1.203) | 0.821 (0.610, 1.106) | 1.307 (0.958, 1.782) | 1.111 (0.736, 1.677) | 1.114 (0.774, 1.604) | 1.081 (0.752, 1.555) | 1.108 (0.503, 2.440) | 0.633 (0.438, 0.916) | 0.483 (0.254, 0.918) | 0.996 (0.730, 1.360) | 0.548 (0.277, 1.081) | 0.977 (0.683, 1.399) | 0.846 (0.646, 1.107) | ||
| 0.981 (0.761, 1.265) | 0.822 (0.615, 1.099) | 1.221 (0.846, 1.762) | CARI | 0.379 (0.017, 8.585) | 0.408 (0.041, 4.108) | 1.241 (0.589, 2.617) | 1.137 (0.820, 1.576) | 0.905 (0.596, 1.373) | 0.858 (0.513, 1.435) | 0.978 (0.710, 1.348) | 1.556 (1.134, 2.135) | 1.323 (0.873, 2.004) | 1.327 (0.918, 1.919) | 1.288 (0.892, 1.859) | 1.319 (0.598, 2.909) | 0.754 (0.518, 1.099) | 0.575 (0.301, 1.096) | 1.186 (0.861, 1.634) | 0.652 (0.330, 1.290) | 1.164 (0.811, 1.672) | 1.007 (0.766, 1.324) | ||
| CHL | 1.077 (0.023, 51.229) | 3.275 (0.136, 79.146) | 3.000 (0.135, 66.806) | 2.387 (0.105, 54.277) | 2.264 (0.098, 52.243) | 2.581 (0.115, 58.009) | 4.106 (0.183, 92.121) | 3.491 (0.154, 79.353) | 3.502 (0.155, 79.075) | 3.399 (0.151, 76.715) | 3.481 (0.142, 85.030) | 1.990 (0.088, 45.024) | 1.517 (0.064, 35.834) | 3.131 (0.139, 70.344) | 1.721 (0.072, 40.997) | 3.072 (0.136, 69.214) | 2.658 (0.119, 59.490) | ||||||
| 1.413 (0.909, 2.197) | 1.184 (0.749, 1.871) | 1.758 (1.050, 2.944) | 1.440 (0.899, 2.306) | END | 3.041 (0.277, 33.368) | 2.785 (0.280, 27.752) | 2.216 (0.219, 22.405) | 2.102 (0.204, 21.685) | 2.396 (0.241, 23.834) | 3.812 (0.384, 37.845) | 3.241 (0.320, 32.779) | 3.251 (0.324, 32.619) | 3.156 (0.315, 31.633) | 3.232 (0.290, 35.978) | 1.848 (0.184, 18.556) | 1.408 (0.132, 15.001) | 2.906 (0.295, 28.608) | 1.598 (0.148, 17.202) | 2.852 (0.285, 28.583) | 2.467 (0.249, 24.432) | |||
| 1.510 (1.099, 2.073) | 1.264 (0.894, 1.789) | 1.878 (1.243, 2.838) | 1.538 (1.080, 2.191) | 1.068 (0.643, 1.775) | ESL | 0.916 (0.447, 1.876) | 0.729 (0.340, 1.562) | 0.691 (0.305, 1.569) | 0.788 (0.386, 1.609) | 1.254 (0.615, 2.555) | 1.066 (0.498, 2.281) | 1.069 (0.512, 2.234) | 1.038 (0.497, 2.166) | 1.063 (0.385, 2.936) | 0.608 (0.290, 1.274) | 0.463 (0.187, 1.147) | 0.956 (0.468, 1.951) | 0.526 (0.207, 1.337) | 0.938 (0.451, 1.953) | 0.811 (0.405, 1.624) | |||
| 0.931 (0.787, 1.102) | 0.780 (0.619, 0.983) | 1.158 (0.834, 1.609) | 0.949 (0.738, 1.220) | 0.659 (0.426, 1.020) | 0.617 (0.450, 0.845) | HAL | 0.796 (0.555, 1.140) | 0.755 (0.471, 1.209) | 0.860 (0.679, 1.090) | 1.369 (1.106, 1.694) | 1.164 (0.814, 1.664) | 1.167 (0.871, 1.564) | 1.133 (0.849, 1.513) | 1.160 (0.541, 2.489) | 0.663 (0.485, 0.907) | 0.506 (0.275, 0.929) | 1.044 (0.824, 1.322) | 0.574 (0.300, 1.099) | 1.024 (0.782, 1.341) | 0.886 (0.741, 1.059) | |||
| 1.214 (0.919, 1.603) | 1.017 (0.745, 1.387) | 1.510 (1.028, 2.218) | 1.237 (0.896, 1.709) | 0.859 (0.531, 1.389) | 0.804 (0.553, 1.170) | 1.304 (0.990, 1.717) | LAM | 0.948 (0.554, 1.624) | 1.081 (0.785, 1.489) | 1.720 (1.215, 2.436) | 1.462 (0.939, 2.278) | 1.467 (0.986, 2.183) | 1.424 (0.957, 2.119) | 1.458 (0.651, 3.265) | 0.834 (0.559, 1.243) | 0.635 (0.327, 1.234) | 1.311 (0.923, 1.862) | 0.721 (0.358, 1.452) | 1.287 (0.868, 1.908) | 1.113 (0.812, 1.526) | |||
| 1.501 (1.014, 2.222) | 1.257 (0.829, 1.907) | 1.867 (1.163, 2.997) | 1.529 (1.002, 2.334) | 1.062 (0.608, 1.855) | 0.994 (0.626, 1.580) | 1.612 (1.090, 2.383) | 1.236 (0.796, 1.920) | LIC | 1.140 (0.715, 1.819) | 1.814 (1.141, 2.884) | 1.542 (0.902, 2.636) | 1.547 (0.937, 2.554) | 1.501 (0.911, 2.475) | 1.538 (0.650, 3.636) | 0.879 (0.530, 1.459) | 0.670 (0.323, 1.389) | 1.383 (0.867, 2.204) | 0.760 (0.355, 1.629) | 1.357 (0.826, 2.228) | 1.174 (0.759, 1.815) | |||
| 1.053 (0.881, 1.260) | 0.882 (0.702, 1.109) | 1.311 (0.951, 1.806) | 1.074 (0.838, 1.375) | 0.745 (0.485, 1.145) | 0.698 (0.511, 0.953) | 1.131 (0.948, 1.350) | 0.868 (0.680, 1.107) | 0.702 (0.476, 1.035) | LIT | 1.591 (1.278, 1.981) | 1.352 (0.951, 1.924) | 1.357 (1.016, 1.812) | 1.317 (0.983, 1.765) | 1.349 (0.630, 2.886) | 0.771 (0.581, 1.023) | 0.588 (0.320, 1.078) | 1.213 (0.975, 1.508) | 0.667 (0.349, 1.273) | 1.190 (0.892, 1.588) | 1.030 (0.871, 1.217) | |||
| 0.963 (0.805, 1.151) | 0.806 (0.662, 0.983) | 1.198 (0.867, 1.655) | 0.981 (0.768, 1.253) | 0.681 (0.447, 1.040) | 0.638 (0.468, 0.869) | 1.034 (0.885, 1.209) | 0.793 (0.609, 1.032) | 0.642 (0.436, 0.944) | 0.914 (0.782, 1.068) | OLA | 0.850 (0.599, 1.206) | 0.853 (0.638, 1.141) | 0.828 (0.633, 1.083) | 0.848 (0.397, 1.810) | 0.485 (0.359, 0.655) | 0.369 (0.202, 0.674) | 0.762 (0.626, 0.928) | 0.419 (0.220, 0.798) | 0.748 (0.565, 0.990) | 0.647 (0.552, 0.758) | |||
| 1.208 (0.807, 1.809) | 1.012 (0.664, 1.543) | 1.503 (0.926, 2.438) | 1.231 (0.796, 1.904) | 0.855 (0.515, 1.419) | 0.800 (0.498, 1.287) | 1.298 (0.871, 1.934) | 0.995 (0.637, 1.555) | 0.805 (0.474, 1.366) | 1.147 (0.776, 1.694) | 1.255 (0.855, 1.840) | OXC | ||||||||||||
| 1.097 (0.837, 1.440) | 0.919 (0.677, 1.248) | 1.365 (0.934, 1.996) | 1.118 (0.816, 1.533) | 0.777 (0.481, 1.255) | 0.727 (0.503, 1.050) | 1.179 (0.903, 1.539) | 0.904 (0.647, 1.263) | 0.731 (0.473, 1.129) | 1.042 (0.805, 1.349) | 1.140 (0.877, 1.481) | 0.908 (0.582, 1.418) | PAL | 1.003 (0.698, 1.441) | 0.974 (0.655, 1.447) | 0.997 (0.446, 2.230) | 0.570 (0.380, 0.855) | 0.434 (0.224, 0.843) | 0.897 (0.630, 1.277) | 0.493 (0.245, 0.991) | 0.880 (0.595, 1.301) | 0.761 (0.557, 1.040) | ||
| 0.985 (0.798, 1.216) | 0.825 (0.640, 1.064) | 1.226 (0.872, 1.722) | 1.004 (0.768, 1.312) | 0.697 (0.446, 1.090) | 0.653 (0.470, 0.906) | 1.058 (0.867, 1.292) | 0.812 (0.611, 1.078) | 0.656 (0.439, 0.981) | 0.935 (0.784, 1.116) | 1.023 (0.841, 1.245) | 0.816 (0.541, 1.229) | 0.898 (0.702, 1.148) | QUE | 0.971 (0.686, 1.372) | 0.994 (0.455, 2.173) | 0.568 (0.398, 0.811) | 0.433 (0.230, 0.817) | 0.894 (0.665, 1.202) | 0.491 (0.251, 0.962) | 0.877 (0.624, 1.232) | 0.759 (0.592, 0.972) | ||
| 0.906 (0.725, 1.131) | 0.758 (0.586, 0.981) | 1.127 (0.795, 1.597) | 0.923 (0.699, 1.218) | 0.641 (0.408, 1.007) | 0.600 (0.429, 0.839) | 0.973 (0.794, 1.192) | 0.746 (0.553, 1.007) | 0.603 (0.401, 0.907) | 0.860 (0.694, 1.065) | 0.940 (0.777, 1.138) | 0.750 (0.495, 1.135) | 0.825 (0.615, 1.107) | 0.919 (0.724, 1.167) | RIS | 1.024 (0.469, 2.237) | 0.586 (0.411, 0.835) | 0.446 (0.246, 0.810) | 0.921 (0.689, 1.230) | 0.506 (0.259, 0.990) | 0.904 (0.645, 1.267) | 0.782 (0.612, 0.999) | ||
| 0.205 (0.051, 0.821) | 0.172 (0.043, 0.693) | 0.255 (0.062, 1.047) | 0.209 (0.052, 0.844) | 0.145 (0.034, 0.614) | 0.136 (0.033, 0.556) | 0.220 (0.055, 0.881) | 0.169 (0.042, 0.686) | 0.137 (0.033, 0.570) | 0.195 (0.049, 0.778) | 0.213 (0.053, 0.851) | 0.170 (0.040, 0.710) | 0.187 (0.046, 0.758) | 0.208 (0.052, 0.835) | 0.226 (0.056, 0.911) | TAM | 0.572 (0.261, 1.254) | 0.436 (0.169, 1.121) | 0.899 (0.420, 1.924) | 0.494 (0.187, 1.304) | 0.882 (0.405, 1.923) | 0.763 (0.363, 1.604) | ||
| 1.673 (1.296, 2.161) | 1.401 (1.046, 1.877) | 2.082 (1.440, 3.008) | 1.705 (1.260, 2.308) | 1.184 (0.740, 1.893) | 1.108 (0.775, 1.585) | 1.797 (1.395, 2.315) | 1.378 (1.004, 1.892) | 1.115 (0.728, 1.706) | 1.588 (1.267, 1.991) | 1.738 (1.362, 2.217) | 1.385 (0.897, 2.138) | 1.525 (1.111, 2.092) | 1.698 (1.305, 2.210) | 1.848 (1.397, 2.444) | 8.165 (2.018, 33.033) | TOP | 0.762 (0.402, 1.443) | 1.573 (1.161, 2.131) | 0.865 (0.440, 1.700) | 1.543 (1.088, 2.190) | 1.335 (1.032, 1.728) | ||
| VALN | 2.064 (1.126, 3.784) | 1.135 (0.482, 2.669) | 2.025 (1.079, 3.802) | 1.752 (0.977, 3.142) | |||||||||||||||||||
| 1.074 (0.858, 1.345) | 0.899 (0.696, 1.162) | 1.336 (0.943, 1.894) | 1.094 (0.829, 1.445) | 0.760 (0.520, 1.111) | 0.711 (0.508, 0.996) | 1.153 (0.929, 1.432) | 0.885 (0.659, 1.188) | 0.716 (0.476, 1.077) | 1.019 (0.835, 1.244) | 1.115 (0.927, 1.342) | 0.889 (0.636, 1.243) | 0.979 (0.730, 1.312) | 1.090 (0.861, 1.380) | 1.186 (0.928, 1.515) | 5.240 (1.302, 21.092) | 0.642 (0.487, 0.846) | VALP | 0.550 (0.288, 1.049) | 0.981 (0.736, 1.308) | 0.849 (0.719, 1.002) | |||
| 1.155 (0.216, 6.168) | 0.968 (0.180, 5.196) | 1.437 (0.264, 7.833) | 1.177 (0.219, 6.331) | 0.818 (0.146, 4.571) | 0.765 (0.141, 4.160) | 1.241 (0.233, 6.621) | 0.952 (0.176, 5.141) | 0.770 (0.139, 4.250) | 1.097 (0.206, 5.849) | 1.200 (0.225, 6.396) | 0.956 (0.173, 5.297) | 1.053 (0.195, 5.678) | 1.173 (0.219, 6.273) | 1.276 (0.238, 6.836) | 5.637 (0.646, 49.176) | 0.690 (0.128, 3.716) | 1.076 (0.201, 5.765) | VER | 1.785 (0.915, 3.482) | 1.544 (0.827, 2.884) | |||
| 1.132 (0.861, 1.487) | 0.948 (0.695, 1.293) | 1.408 (0.958, 2.069) | 1.153 (0.836, 1.590) | 0.801 (0.494, 1.299) | 0.750 (0.516, 1.089) | 1.215 (0.947, 1.560) | 0.932 (0.662, 1.313) | 0.754 (0.486, 1.169) | 1.074 (0.819, 1.409) | 1.175 (0.902, 1.531) | 0.937 (0.598, 1.468) | 1.031 (0.737, 1.442) | 1.149 (0.861, 1.533) | 1.250 (0.930, 1.679) | 5.522 (1.359, 22.430) | 0.676 (0.489, 0.935) | 1.054 (0.781, 1.421) | 0.980 (0.181, 5.289) | ZIP | 0.865 (0.683, 1.096) | |||
| 1.529 (1.327, 1.762) | 1.281 (1.049, 1.563) | 1.902 (1.409, 2.567) | 1.558 (1.262, 1.924) | 1.082 (0.710, 1.648) | 1.013 (0.763, 1.345) | 1.642 (1.432, 1.883) | 1.259 (0.986, 1.608) | 1.019 (0.706, 1.469) | 1.451 (1.275, 1.652) | 1.588 (1.403, 1.797) | 1.266 (0.865, 1.853) | 1.393 (1.102, 1.761) | 1.552 (1.316, 1.830) | 1.689 (1.411, 2.021) | 7.461 (1.876, 29.678) | 0.914 (0.736, 1.135) | 1.424 (1.188, 1.707) | 1.324 (0.249, 7.023) | 1.351 (1.061, 1.721) | PLA |
Drugs are reported alphabetically. Data are presented as risk ratios (95% confidence interval) in the column-defining treatment compared with the row-defining treatment. For efficacy, risk ratios >1 favor the column-defining treatment. For acceptability, risk ratios <1 favor the row-defining treatment.
Significant results are in bold.
ARI aripiprazole, ASE asenapine, BRE brexpiprazole, CARB carbamazepine, CARI cariprazine, CHL chlorpromazine, END endoxifen, ESL eslicarbazepine, HAL haloperidol, LAM lamotrigine, LIC licarbazepine, LIT lithium, OLA olanzapine, OXC oxcarbazepine, PAL paliperidone, PLA placebo, QUE quetiapine, RIS risperidone, TAM tamoxifen, TOP topiramate, VALN valnoctamide, VALP valproate, VER verapamil, ZIP ziprasidone.