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. 2022 Jan 27;27(2):1256–1273. doi: 10.1038/s41380-021-01351-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — miR-20b was quantified in temporal lobe (TL), cerebellum (CB), and posterior cingulate cortex (PCC) samples as described in the main text. Effect of miR-20b levels on probability of diagnosis (NCI/MCI/AD) was then modeled. A–C Comparison of absolute quantitation by diagnosis and brain region. D–F Comparison of ΔΔC_T (fold change) quantitation by diagnosis and brain region. Symbols indicate estimated marginal means categories. IQR: Interquartile range for miR-20b within a brain region. x̃: Median of miR-20b within a brain region. Significant effects are indicated by line colors and patterns, to wit: NCI, APOE ε4 absent: ; NCI, ε4 present: ; MCI, ε4 absent: ; MCI, ε4 present: ; AD, ε4 absent: ; AD, ε4 present:. Finally, miR-20b-5p axes for all charts is log scale.

Inline graphic — miR-20b was quantified in temporal lobe (TL), cerebellum (CB), and posterior cingulate cortex (PCC) samples as described in the main text. Effect of miR-20b levels on probability of diagnosis (NCI/MCI/AD) was then modeled. A–C Comparison of absolute quantitation by diagnosis and brain region. D–F Comparison of ΔΔC_T (fold change) quantitation by diagnosis and brain region. Symbols indicate estimated marginal means categories. IQR: Interquartile range for miR-20b within a brain region. x̃: Median of miR-20b within a brain region. Significant effects are indicated by line colors and patterns, to wit: NCI, APOE ε4 absent: ; NCI, ε4 present: ; MCI, ε4 absent: ; MCI, ε4 present: ; AD, ε4 absent: ; AD, ε4 present:. Finally, miR-20b-5p axes for all charts is log scale.