Fig. 9. Illustration of the opening and closing conformational change of the unbound and bound menG protein. (A) Unbound systems superimposed snapshot at 0, 0.5, 150, 300 ns showing the active site opening of Thompson loop (yellow) and (B) bound systems superimposed picture at 0, 0.5, 150, 300 ns showing the active site closing conformation by Thompson loop (yellow).