Table 5.
Incidence rates/100 patient-years (95% CI) | (A) PS-trimmed cohort | (B) PS-matched cohort | ||
---|---|---|---|---|
Dabigatran n = 3585 |
Apixaban n = 4145 |
Dabigatran n = 2683 |
Apixaban n = 2683 |
|
Composite outcome* | 2.35 (2.00–2.72) | 2.55 (2.22–2.90) | 2.55 (2.12–2.98) | 2.30 (1.90–2.69) |
Stroke | 0.85 (0.65–1.07) | 0.73 (0.56–0.90) | 0.86 (0.62–1.13) | 0.77 (0.54–1.02) |
GI bleeding | 0.35 (0.22–0.50) | 0.31 (0.20–0.42) | 0.41 (0.25–0.58) | 0.21 (0.10–0.35) |
ICH bleeding | 0.18 (0.08–0.28) | 0.24 (0.15–0.35) | 0.17 (0.07–0.28) | 0.22 (0.11–0.33) |
Major bleeding | 0.68 (0.50–0.86) | 0.93 (0.74–1.12) | 0.75 (0.53–0.98) | 0.78 (0.56–1.02) |
Myocardial infarction | 0.42 (0.28–0.57) | 0.71 (0.55–0.89) | 0.45 (0.28–0.63) | 0.55 (0.37–0.75) |
All-cause death | 2.18 (1.84–2.51) | 2.71 (2.39–3.05) | 2.35 (1.96–2.74) | 2.56 (2.16–2.98) |
PS propensity score; CI confidence interval; GI gastrointestinal; ICH intracerebral
*Composite outcome of stroke, systemic embolism, myocardial infarction, life-threatening bleeding events, and vascular death