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. 2021 Oct 19;25(2):205–224. doi: 10.1007/s10456-021-09822-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Canonical Notch signaling in LECs is unaltered in the Notch4 mutant dermal lymphatics. Notch4^+/−;ProxTOM^+/;NVR^+/− males were bred with Notch4^+/−;ProxTom^+/;NVR^+/− females, and E14.5 ProxTom; NVR and Notch4^−/−;ProxTom;NVR dermal wholemounts stained for LYVE1. a Representative images of blunted-ended and spiky-ended sprouts at the lymphangiogenic front of wild-type (WT) and Notch4^−/− dermis. b Representative images of branch-points with Notch signaling in WT and Notch4^−/− in the maturing lymphatic vascular plexus. Scale bars, 50 μm