TABLE 2.
Population and posterior estimates of pharmacokinetic parameters for quinineb
| Parameter | Result for
|
|
|---|---|---|
| Population estimate (CV, %) | Post hoc estimate (CV, %) | |
| CL (liter/h/kg)a | 0.05 (73.6) | 0.05 (18.9) |
| V1 (liter/kg) | 0.65 (48.9) | 0.65 (36.4) |
| Q (liter/h/kg) | 1.12 (47.6) | 1.12 (15.4) |
| Vp (liter kg−1) | 0.764 (44.9) | 0.76 (20.6) |
| ka (h−1) | 3.5 | |
| t1/2ab (h) | 0.2 | |
| Vss (liter/kg) | 1.41 | 1.41 (19.0) |
| t1/2β (h) | 19.7 | 19.9 (22.0) |
a
Log normal distribution.
b
Vss, volume at steady state; t1/2ab, absorption half-life; t1/2β, elimination half-life; ka is fixed at 3.5. CV, intersubject variability. No covariates.