Solvent screening for Sonogashira cross-coupling reaction of iodobenzene and phenyl acetylene^a.

Entry	Solvent	GC-MS (% conversion)	Isolated yield (%)
1	C 2 H 5 OH	100	99
2	H2O	—	—
3	i-PrOH	89	81
4	CH3OH	57	32
5	DCM	—	—
6	DMF	—	—
7	DMSO	—	—
8	CH3CN	50	32
9	CHCl3	—	—
10	CCl4	—	—
11	C2H5OH	—	—b
12	C2H5OH	10	7c
13	C2H5OH	—	—d

^aReaction conditions: iodobenzene (1 mmol), phenyl acetylene (1 mmol), base (Et₃N, 10 mL), solvent (10 mL), catalyst (Pd/Cu@GO, 0.0001176 wt% Pd and 0.0002515 wt% Cu), otherwise noted.

^bGO.

^cNano Pd@GO.

^dNano Cu@GO, temperature = 75 °C.