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. 2022 Apr 29;13:2361. doi: 10.1038/s41467-022-30084-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The chemical structure of darobactin. The key C–O–C and C–C crosslinks that consist the unique bicyclic scaffold of darobactin are highlighted in blue. b The darobactin BGC from Photorhabdus khanii HGB1456 encodes a precursor peptide DarA_pk, an rSAM enzyme DarE_pk, and three ABC transports DarBCD_pk. The core sequence of DarA_pk (DarA_pk(49-55)) is shown in bold.