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. 2022 Apr 28;17(1):826–840. doi: 10.1515/med-2022-0428

Figure 4.

Figure 4

Exosome-carried circ_0000519 regulates NSCLC cell growth and metastasis. (a) circ_0000519 expression was measured using qRT-PCR in the exosomes of H1299 cells transfected with si-NC or si-circ_0000519. The exosomes were isolated from the H1299 cells transfected with si-NC or si-circ_0000519 and then co-incubated with H2170 and A549 cells. (b) circ_0000519 level was measured with qRT-PCR in H2170 and A549 cells after the co-incubation of exosomes. (c and d) Cell growth was analyzed using EdU staining and colony formation assays in H2170 and A549 cells after co-incubation of exosomes. (e and f) Cell migration and invasion were examined through the transwell analysis in H2170 and A549 cells after co-incubation of exosomes. (g and h) Cyclin D1, Vimentin, and MMP9 levels were measured via Western blotting in H2170 and A549 cells after co-incubation of exosomes. *** P < 0.001.