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. 2022 Apr 28;17(1):826–840. doi: 10.1515/med-2022-0428

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© 2022 Rui Wang et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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Exosomal circ_0000519 regulates xenograft tumor growth. The murine xenograft model was induced by injection of H2170 cells, and tumors were treated with the exosomes from H1299 cells transfected with sh-NC or sh-circ_0000519 (named sh-NC-exo or sh-circ_0000519-exo) after 5 days. (a and b) Tumor volume and weight were examined in each group. n = 5. (c) The Ki-67 level was detected by an immunohistochemistry assay. (d and e) circ_0000519, miR-1258, and RHOV abundances were examined via qRT-PCR and Western blotting in each group. ^*** P < 0.001.