| Kefiran extracted from Portuguese kefir grains |
• Kefiran possesses pseudoplastic behaviour and adhesive performance which help the adhesion of drug molecules to biological surfaces or for biofilm formation |
68
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| • Its pseudoplastic behaviour and gelation ability make it as a suitable polymer to be the matrix environments of various therapeutic agents such as stem cells, proteins, and genetically engineered cells |
| • Kefiran has a higher resistance towards the hyaluronidase degradation (enzymatic resistance) |
| • It owns high potentials in bone defects and articular cartilage applications due to its mechanical and viscoelastic characteristics |
| Kefiran |
• Oral administration of kefiran enhances the balance of immune cells in intestinal mucosa due to its probiotic effects |
99
|
| • Kefiran is capable to modify cytokine and immunoglobulin profiles |
| • It is possible to trigger an immune response. Therefore, contribute to intestinal homeostasis |
| Kefiran |
• Orally administrated kefiran from Lb. kefiranofaciens can promote the number of IgA+ cells in both small and large intestine lamina propria without affecting the number of IgG+ cells |
100
|
| • It can induce immune response and enhance the intestinal homeostasis |
| Kefiran |
• Kefiran has the potential to be a stress-reducing food supplement due to its capability in improving the production of noradrenaline and interferon B-cortisol in human cell lines |
102
|
| Kefiran-derived from Tibetan kefir grains |
• The isolated kefiran was identified with high antioxidant activity which shields proteins from oxidative damage in a dose-dependent pattern |
103
|
| • It has a good thermal stability |
| • It is an ideal candidate as a natural antioxidant supplement |
| • It can be also be applied widely in food industries as functional food or ingredients |
|
Lactobacillus kefiranofaciens-derived kefiran |
• Kefiran is effective in lowering the blood pressure, cholesterol, and glucose levels in rats and mice |
104
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| • The in vivo study also indicated kefiran is capable to improve the fecal wet weight and moisture level in constipated rats |
| Kefiran |
• Orally administrated kefiran possesses bifidogenic effect on the intestinal microbiota of the studied mice (BALB/c) in animal trials |
105
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| • The increased Bifidobacterium level in the GIT of infants helps to minimize the incidence of allergic disease in later stage of life |
