TABLE 2.
Interlaboratory agreement on broth microdilution antifungal susceptibility for Aspergillus spp.a
| Antifungal agent and MIC criterion | % Agreement [all isolates (itraconazole-susceptible isolates)]
|
|||
|---|---|---|---|---|
| RPMI | RPMI-2% | M3 | M3-2% | |
| Itraconazole | ||||
| MIC-0 | 90 (92) | 92 (94) | 90 (91) | 85 (85) |
| MIC-2 | 83 (89) | 88 (94) | 84 (92) | 88 (97) |
| Posaconazole | ||||
| MIC-0 | 91 (91) | 88 (87) | 94 (94) | 86 (86) |
| MIC-2 | 96 (96) | 95 (96) | 93 (99) | 91 (96) |
| Ravuconazole | ||||
| MIC-0 | 93 (95) | 87 (85) | 94 (95) | 88 (89) |
| MIC-2 | 88 (89) | 90 (89) | 85 (86) | 81 (82) |
| Voriconazole | ||||
| MIC-0 | 97 (97) | 98 (99) | 99 (100) | 93 (92) |
| MIC-2 | 88 (96) | 94 (95) | 90 (92) | 96 (96) |
a
Species tested were A. fumigatus (n = 9), A. flavus (n = 3), and A. terreus (n = 3); 48-h MICs are shown.