TABLE 5.
Ravuconazole (BMS-207147) MICs for Aspergillus spp. in eight laboratoriesa
| Isolate(s) (no. tested) and MIC criterion | MIC range (MIC90 or modal MIC)b
|
|||
|---|---|---|---|---|
| RPMI | RPMI-2% | M3 | M3-2% | |
| Itraconazole susceptible (12) | ||||
| MIC-0 | 0.12–4 (2) | 0.12–>8 (1) | 0.2–>8 (4) | 0.2–>8 (4) |
| MIC-2 | 0.01–1 (1) | 0.01–0.5 (0.5) | 0.01–4 (1) | 0.06–1 (1) |
| Itraconazole resistant (isolate no. 5) | ||||
| MIC-0 | 0.2–0.5 (0.2) | 0.12–1 (0.2) | 0.2–8 (0.5) | 0.12–4 (1) |
| MIC-2 | 0.01–0.2 (0.12) | 0.03–0.12 (0.06) | <0.008–0.5 (0.12) | 0.008–0.5 (0.06) |
| Itraconazole resistant (isolate no. 6) | ||||
| MIC-0 | 2–8 (2) | 1–>8 (2) | 1–>8 (8) | 2–>8 (8) |
| MIC-2 | 0.2–4 (0.5) | 0.12–1 (1) | 0.2–4 (2) | 0.062–8 (2) |
| Voriconazole-resistant mutant (1) | ||||
| MIC-0 | 2–>8 (4) | 1–4 (2) | 4–>8 (>8) | 2–>8 (8) |
| MIC-2 | 0.12–4 (1) | 0.06–1 (0.5) | 0.06–2 (0.5) | 0.03–1 (0.2) |
a
Species tested were A. fumigatus (n = 9), A. flavus (n = 3), and A. terreus (n = 3); see Table 1 for reported data regarding isolates 5 and 6; 48-h MICs are shown.
b
MICs are reported in micrograms per milliliter; the MIC90 is reported for susceptible isolates and the modal MIC is reported for single resistant isolates.