Fig. 6. (a) Predicted ADME properties of 5i as obtained from the report generated by SwissADME software. (b) BOILED EGG representation of 5i (denoted as Molecule 1 and represented by blue dot in the figure). From the BOILED EGG representation, the yolk denotes the points which allows passive blood–brain-barrier permeation, while the white region denotes points for passive gastrointestinal tract absorption. The graph is plotted against W log P[a log P(n-octanol/water partition coefficient) method developed by Wildman and Crippen] versus TPSA or Topological Polar Surface Area.