Results of AChE inhibition and anti-oxidant values.
| |||||
|---|---|---|---|---|---|
| Compound | Ar | EeAChE IC50 ± SEMa (mM) | ORAC index ± SEMb | ||
| 5a |
|
>10 | 1.0564 | ±0.3604 | |
| 5b |
|
3.3833 | ±0.0927 | 1.8428 | ±0.0980 |
| 5c |
|
1.3759 | ±0.1019 | 2.0164 | ±0.0538 |
| 5d |
|
0.9073 | ±0.0924 | 1.9723 | ±0.4236 |
| 5e |
|
4.5737 | ±0.0995 | 1.8862 | ±0.2533 |
| 5f |
|
2.6508 | ±0.1694 | 2.3425 | ±0.0228 |
| 5g |
|
6.4687 | ±0.1334 | 1.4489 | ±0.1579 |
| 5h |
|
1.5437 | ±0.0227 | 2.1015 | ±0.0315 |
| 5i |
|
1.5609 | ±0.0237 | 1.2138 | ±0.2832 |
| 5j |
|
2.7187 | ±0.0435 | 1.9697 | ±0.1800 |
| 5k |
|
2.70723333 | ±0.0127 | 0.8358 | ±0.0374 |
| 5l |
|
3.3777 | ±0.2162 | 1.9421 | ±0.1603 |
| 5m |
|
3.1383 | ±0.0432 | 1.215 | ±0.1383 |
| 5n |
|
1.0801 | ±0.0851 | 2.2079 | ±0.1003 |
| 5o |
|
6.5162 | ±0.1326 | 2.0758 | ±0.1775 |
| 5p |
|
3.6525 | ±0.0120 | 0.8718 | ±0.2761 |
| 5q |
|
1.1346 | ±0.1632 | 0.7168 | ±0.1410 |
| Pyridoxine | — | n.ac | 0.5249 | ±0.1084 | |
| Donepezil | — | <5 μM | N.Td | ||
| Trolox | — | N.Td | 1 | ||
a
IC50 values is the concentration of the enzyme required to decrease the enzyme activity by 50% and are the mean of three independent experiments, represented in mean ± SEM (SEM = standard error mean).
b
The mean ± SEM of three independent experiments. Data are represented as ORAC-FL values of Trolox equivalents (μM of tested compound/μM of Trolox).
c
n.a = not active.
d
N.T = not tested.