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. 2020 Jul 9;10(44):26006–26021. doi: 10.1039/d0ra04942e

Percentage of AChE inhibition of 5c, 5d, 5h, 5i, 5n, 5q and donepezil at different concentrations of the compoundsa.

156 μM 312 μM 625 μM 1.25 mM 2.5 mM 5 mM 10 mM
% ±SEM % ±SEM % ±SEM % ±SEM % ±SEM % ±SEM % ±SEM
5c 22.49 3.62 26.92 0.55 39.11 2.48 53.8 3.13 64.11 1.79 73.43 1.13 81.92 0.85
5d 33.53 6.44 36.41 6.8 51.15 5.55 58.56 4 69.57 2.3 81.3 2.36 86.03 0.63
5h 19.04 0.29 25.49 2.22 35.1 1.59 56.37 1.85 60.48 1.24 66.56 0.26 69.02 0.36
5i 14.97 4.12 26.58 3.92 35.38 0.47 43 1.52 61.41 2.82 66.78 0.1 77.89 0.15
5n 14.69 1.15 25.79 2.73 41.99 1.42 57.39 4.99 70.16 4.11 75.88 2.44 86.28 1.38
5q 22.49 3.62 26.92 0.55 39.11 2.48 53.8 3.13 64.11 1.79 73.43 1.13 81.92 0.85
Donepezil 89.07 1.19 94.5 0.81 97.44 0.73 100.88 0.93 99.7 1.04 99.74 0.69 99.95 0.48
a

Data presented here is of % of AChE inhibition mean ± SEM of three independent experiments at different concentrations. Donepezil is taken as the reference compound.