Percentage of AChE inhibition of 5c, 5d, 5h, 5i, 5n, 5q and donepezil at different concentrations of the compoundsa.
156 μM | 312 μM | 625 μM | 1.25 mM | 2.5 mM | 5 mM | 10 mM | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
% | ±SEM | % | ±SEM | % | ±SEM | % | ±SEM | % | ±SEM | % | ±SEM | % | ±SEM | |
5c | 22.49 | 3.62 | 26.92 | 0.55 | 39.11 | 2.48 | 53.8 | 3.13 | 64.11 | 1.79 | 73.43 | 1.13 | 81.92 | 0.85 |
5d | 33.53 | 6.44 | 36.41 | 6.8 | 51.15 | 5.55 | 58.56 | 4 | 69.57 | 2.3 | 81.3 | 2.36 | 86.03 | 0.63 |
5h | 19.04 | 0.29 | 25.49 | 2.22 | 35.1 | 1.59 | 56.37 | 1.85 | 60.48 | 1.24 | 66.56 | 0.26 | 69.02 | 0.36 |
5i | 14.97 | 4.12 | 26.58 | 3.92 | 35.38 | 0.47 | 43 | 1.52 | 61.41 | 2.82 | 66.78 | 0.1 | 77.89 | 0.15 |
5n | 14.69 | 1.15 | 25.79 | 2.73 | 41.99 | 1.42 | 57.39 | 4.99 | 70.16 | 4.11 | 75.88 | 2.44 | 86.28 | 1.38 |
5q | 22.49 | 3.62 | 26.92 | 0.55 | 39.11 | 2.48 | 53.8 | 3.13 | 64.11 | 1.79 | 73.43 | 1.13 | 81.92 | 0.85 |
Donepezil | 89.07 | 1.19 | 94.5 | 0.81 | 97.44 | 0.73 | 100.88 | 0.93 | 99.7 | 1.04 | 99.74 | 0.69 | 99.95 | 0.48 |
Data presented here is of % of AChE inhibition mean ± SEM of three independent experiments at different concentrations. Donepezil is taken as the reference compound.