Fig. 1. (A) RdRP structure in the cupped righthand form bound to remdesivir (RDV) with the three subdomains finger (red) (residues 398–581 and 621–679), palm (cornflower blue) (residues 582–627) and thumb (green) (residues 688–815). (B) The conserved motifs (A–G) surrounding the inhibitor binding cavity. (C) 2-d representation of the inhibitor remdesivir (RDV), Sp isomer.
