Fig. 1. Schematic illustration of the polymer functionalization on the silica surface and the cargo controlled release mechanism of dual temperature and pH responsive gated polyphosphazene units (PPz). The material was initially uploaded with safranin O and grafted with azide moieties (MSN1-SAF-AZ) following the attachment of the polymer to the surface of silica mesopores via click chemistry (MSN1-SAF-PPz). The scheme of PPz shows the simplified structure of the statistically distributed Jeffamine® M-2005 moieties along the polymer backbone (n ∼ 50). Cargo release occurs by increasing the temperature above LCST of PPz due to collapsing of the polymer and opening the pores.