Amphotericin B |
Compritol® ATO 888, Precirol ATO 5 and stearic acid, |
Pluronic® F-68, Pluronic® F-127, |
|
Solvent diffusion method |
DLS, DSC, zeta potential |
111–415.8 |
37
|
Compritol® ATO 888 (glycerylbehenate), glycerylpalmitostearate (Precirol® ATO 5), medium chain triglyceride |
Tween 20, Pluronic® F-127, Cremophor RH40, polyoxyethylene (40) stearate (Myrj 52) |
HPH |
DLS, zeta potential, HPLC, TEM, FTIR, DSC, PXRD, 1H NMR |
90–260 |
38
|
Baclofen |
Stearic acid |
Epikuron 200 (92% phosphatidylcholine) |
Propionic acid, butyric acid, and sodium taurocholate |
Multiple (w/o/w) warm, microemulsion |
DLS |
161.4 |
39
|
BuspironeHCl |
Cetyl alcohol, Spermaceti |
Pluronic® F-68, Tween 80 |
|
Emulsification-evaporation followed by ultrasonication |
DLS |
86–123 |
40
|
Camptothecin |
Soybean lecithin, stearic acid |
Pluronic® F-68, Tween 80 |
Glycerol, PEG 400, PPG |
Hot HPH |
TEM |
196.8 |
41
|
Carvedilol |
Stearic acid |
Pluronic® F-68 |
Sodium taurocholate and ethanol |
Microemulsion |
TEM, DLS |
120–200 and 600–800 |
42
|
Clozapine |
Trimyristin, tripalmitin, tristearin, soy phosphatidylcholine |
Pluronic® F-68 |
|
Ultrasonication method |
DLS, zeta potential |
96.7 ± 3.8 to 163.3 ± 0.7 |
43
|
Crypto-Tanshinone |
Glycerylmonostearate, Compritol 888 ATO |
Soy lecithin, Tween 80, sodium dehydrocholate |
|
Ultrasonic and high-pressure homogenization method |
TEM, DLS, DSC |
121.4 ± 6.3 and 137.5 ± 7.1 |
44
|
Curcumin |
Compritol 888 ATO |
Soy lecithin, Tween 80 |
|
Microemulsion |
DLS, TEM |
134.6, 40–120 |
45
|
Tristearin |
Polyoxyethylene (10) stearyl ether (Brij®S10), polyoxyethylene (100) stearyl ether (Brij® S100) |
Oil-in-water emulsion technique |
PCS, zeta potential |
111–350 |
45
|
Cyclosporine A |
Imwitor® 900 |
Tagat®S, sodium cholate |
|
HPH, hot HPH |
DLS |
157, 143 |
46 and 47
|
Diazepam |
Compritol 888 ATO, Imwitor® 900 |
Pluronic® F-68, Tween 80 |
|
Ultrasound techniques modified high-shear homogenization and |
TEM |
<500 |
48
|
Doxorubicin hydrochloride |
Glycerylcaprate |
Polyethylene glycol 660 hydrox-ystearate (Solutol®HS15) |
|
Ultrasonic homogenization |
DLS, zeta potential, DSC |
199 |
49
|
Fenofibrate |
Vitamin E TPGS, Vitamin E 6–100 |
|
|
Hot HPH |
DLS |
58 |
50
|
Hydrocortisone |
Precirol® ATO 5, Compritol® 888 ATO, Rylo TM MG 14 Pharma, Dynasan® 114 Dynasan® 118, Tegin® 4100 |
Tween 80 |
|
Hot high pressure homogenization |
DLS, DSC |
150–220 |
51
|
Ibuprofen |
Trilaurin, tripalmitin, stearic acid |
Pluronic®F127, sodium taurocholate |
|
Solvent-free high-pressure homogenization (HPH) |
DLS, X-ray powder diffraction, DSC, AFM |
111–121 (empty SLN) 175–189 (loaded sample) |
52
|
Idarubicin |
Stearic acid |
Epikuron 200 (soy phosphatidylcholine 95%) |
Taurocholate sodium salt |
Microemulsion |
PCS, 90 PLUS |
80 ± 10((loaded sample)) |
53
|
Emulsifying wax |
Polyoxyl 20-stearyl ether (Brij 78), D-alpha-tocopheryl polyethylene glycol succinate (vitamin E TPGS),DSPE-PEG3000
|
Sodium taurodeoxycholate (STDC), sodium tetradecylsulfate (STS) |
PCS, Zetasizer nano Z |
94.4 (blank), 80–104 (loaded sample) |
54
|
Ketoprofen |
Beeswax and carnauba wax |
Tween 80, egg lecithin |
|
Microemulsion technique |
PCS, DSC |
65–250 (loaded sample) |
55
|
Lopinavir |
Compritol 888 ATO (glycerylbehenate) |
Pluronic®F127 |
|
Hot homogenization, ultrasonication |
DLS, zeta potential, HPLC, DSC, WAXS, AFM |
230 |
56
|
Lovastatin |
Triglyceride, and phosphatidylcholine 95% |
Pluronic®F68 |
|
Hot homogenization ultrasonication |
DLS, HPLC, DSC, PXRD, LC-MS/MS |
60–119 |
57
|
Methotrexate |
Stearic acid, monostearin, tristearin, and Compritol 888 ATO |
l-α-Soya lecithin, and Sephadex G-50 |
|
Solvent diffusion method |
DLS, zeta potential, TEM |
120–167 |
58
|
Nevirapine |
Steric acid, Compritol 888 ATO |
Dimethyldioctadecyl ammonium bromide (DODAB), Tween 80, Lecithin |
1-Butanol |
Microemulsion |
DLS, zeta potential, field emission scanning electron microscopy (FE-SEM), DSC |
153.1 |
59
|
Nitrendipine |
triglyceride and phosphatidylcholine |
Pluronic®F68 |
|
Hot homogenization ultrasonication method |
DLS, zeta potential, scanning electron microscopy (SEM) |
110–140 |
60
|
Octadecylamine-fluorescein isothiocyanate |
Stearic acid |
Otcadecylamine, polyethylene glycol monostearate (PEG2000-SA) |
|
Solvent diffusion |
DLS, zeta potential |
203 |
61
|
Pentoxifylline |
Stearic acid, cetyl alcohol, soy lecithin, |
Tween 20, Pluronic F®68 |
|
Homogenization followed by the ultrasonication |
DLS, zeta-potential |
255–4000 |
62
|
Praziquantel |
Hydrogenated castor oil |
Poly vinyl alcohol (PVA) |
|
Hot homogenization and ultrasonication |
DLS, zeta-potential, SEM |
344.0 |
63
|
Puerarin |
Monostearin, and soy lecithin |
Pluronic F®68 |
|
Solvent injection method |
DLS and zeta-potential |
160 |
64
|
Quercetin |
Glycerylmonostearat, soy lecithin |
Tween-80 and PEG 400 |
|
Emulsification-solidification |
DLS, zeta-potential, TEM |
|
65
|
Rifampicin |
Stearic acid |
PVA |
|
Emulsion-solvent diffusion |
|
|
66
|
Tobramycin |
Stearic acid |
Epikuron 200 |
Sodium taurocholate |
Microemulsion |
DLS, TEM |
70–100 |
67
|
Vinpocetine |
Glycerylmonostearat, soy lecithin, polyoxyethylene hydrogenated castor oil |
Tween 80 |
|
Ultrasonic-solvent emulsification |
DLS, TEM |
70–170 |
68
|