TABLE 2.
Parasitic pattern in P. falciparum-huRBC–BXN model after treatment with conventional antimalarial drugs
| Drug | Strain | Day 0
|
Day 1
|
Day 2
|
Day 3
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % of rings | % of trophozoites | % of schizonts | % of rings | % of altered trophozoites | % of pycnotic forms | % of rings | % of altered trophozoites | % of pycnotic forms | % of rings | % of altered trophozoites | % of pycnotic forms | ||
| Chloroquine | NF54 | 78 | 4 | 18 | 10 | 26 | 64 | 0 | 0 | 100 | 0 | 0 | 100 |
| Mefloquine | NF54 | 59 | 5 | 36 | 7 | 72 | 21 | 3 | 43 | 54 | 0 | 0 | 100 |
| Dihydroartemisinin | T24 | 51a | 0a | 22a | 4b | 16b | 76b | 0 | 0 | 100 | 0 | 0 | 100 |
a
The percentages of pycnotic forms and altered trophozoites after chloroquine treatment were 16 and 11%, respectively.
b
The percentages of trophozoites and schizonts were 1 and 3%, respectively.