Scheme 1. Reagents and conditions: (a) CH3OH, H2SO4, 4 h, 35 °C (b) DIPEA, DCM, acetone, MOMBr, 2 h, reflux (c) LiAlH4, dry THF, 3 h, rt (d) DMP, DCM, NaHCO3, 4 h, 0 °C (e) MOMBr, K2CO3, acetone, 5 h, reflux (f) H2O, 10% NaOH, acetone, rt (g) LDA, THF, 5 h, −78 °C (h) HCl (6 mol L−1), methanol, 15 min, 60 °C, reflux.
