Docking scores of the top 20 hits identified in addition to lopinavir, nelfinavir and remedesivir against the three viral proteins studied.

	3CLpro			PLpro			RdRp
	Compound	Docking score	Plant source	Compound	Docking score	Plant source	Compound	Docking score	Plant source
1		−12.632	Anastatica hierochuntica, Allium myrianthum, Glycyrrhiza glabra		−14.041	Cichorium intybus, Marrubium vulgare, Olea europaea		−11.541	Cichorium intybus
2		−11.844	Glycyrrhiza glabra		−13.883	Cynara scolymus		−10.664	Marrubium vulgare, Olea europaea, Cichorium intybus
3		−11.721	Cichorium intybus, Marrubium vulgare, Olea europaea		−11.148	Marrubium vulgare, Olea europaea, Cichorium intybus		−9.894	Trigonella foenum-graecum
4		−11.624	Cichorium intybus, Hibiscus sabdariffa		−10.832	Glycyrrhiza glabra		−9.797	Tribulus terrestris
5		−11.412	Glycyrrhiza glabra		−10.674	Ephedra alata		−9.785	Eruca sativa
6		−11.409	Sonchus macrocarpus		−10.658	Salvia triloba		−9.754	Hibiscus sabdariffa
7		−11.363	Glycyrrhiza glabra		−10.593	Glycyrrhiza glabra		−9.747	Matricaria chamomilla
8		−11.119	Terminalia species, Tamarix nilotica, Quercus suber		−10.504	Centaurea furfuracea		−9.732	Glycyrrhiza glabra
9		−11.061	Hibiscus sabdariffa		−10.49	Artemisia judaica		−9.611	Glycyrrhiza glabra
10		−11.015	Artemisia herba-alba		−10.402	Matricaria chamomilla		−9.544	Medicago sativa
11		−11.015	Epilobium hirsutum		−10.338	Phyllanthus emblica, Globularia alypum		−9.527	Tribulus terrestris
12		−10.892	Schinus molle		−10.255	Phyllanthus emblica		−9.509	Cleome species
13		−10.88	Lepidium sativum, Cleome species, Tribulus terrestris		−10.201	Glycyrrhiza glabra		−9.493	Trigonella foenum-graecum
14		−10.831	Schinus molle		−10.182	Tetraclinis articulata		−9.485	Fraxinus oxycarba
15		−10.811	Crataegus sinaica		−10.18	Olea europaea		−9.484	Glycyrrhiza glabra
16		−10.762	Olea europaea		−10.162	Cynara scolymus		−9.403	Artemisia judaica
17		−10.695	Olea europaea		−10.041	Podocarpus gracilior		−9.361	Glycyrrhiza glabra
18		−10.684	Cicer arietinum		−10.035	Glycyrrhiza glabra		−9.31	Scrophularia saharae
19		−10.658	Hibiscus sabdariffa		−10.027	Anastatica hierochuntica		−9.298	Salvia triloba
20		−10.624	Artemisia herba-alba, Artemisia judaica		−10.027	Glycyrrhiza glabra		−9.278	Tribulus terrestris
		−10.195		Lopinavir	−8.625		Lopinavir	−5.94
		−8.297		Nelfinavir	−4.324		Nelfinavir	−7.594
		−7.346		Remdesivir	−3.947		Remdesivir	−8.526