Fig. 8. The 2-D interaction profiles of the HTS hit compounds 49 (ML300; 4mds.pdb) and 48 (ML188; 3v3m.pdb) in the active site residue of SARS-CoV-1 3CLpro; hydrogen bonds are shown with broken lines, and hydrophobic interactions are shown in green. The picture was prepared using the “poseview” tool.