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Fig. 6. Visual representation as visualized by Vida. (A) Compound 21 in the catalytic domain of PDE5 (PDB code: 2H24); (B) compound 5a in the catalytic domain of PDE5 (PDB code: 2H24); (C) compound 23b with a hydrophobic–hydrophobic interaction without the formation of a HB; (D) overlay between compounds 5a and 21.