Table 5.
Effects of H. sabdariffa calyxes extract on some hematological parameters after 21 weeks post-DMBA exposition.
| Parameters | NOR | DMBA | TAMOX + DMBA | H. sabdariffa + DMBA | ||
|---|---|---|---|---|---|---|
| 125 | 250 | 500 | ||||
| WBC (×103 µL−1) | 10.60 ± 1.09 | 21.56 ± 1.96## | 12.00 ± 1.91∗ | 14.99 ± 2.61 | 25.14 ± 3.45 | 12.00 ± 1.78∗ |
| Lymphocytes (%) | 78.04 ± 2.56 | 43.81 ± 6.55### | 70.02 ± 5.26∗∗ | 58.5 ± 6.98 | 33.24 ± 2.05 | 68.22 ± 4.70∗∗ |
| Monocytes (%) | 19.21 ± 2.71 | 47.14 ± 5.45### | 16.12 ± 4.30∗∗∗ | 8.53 ± 1.78∗∗∗ | 37.86 ± 6.37 | 26.81 ± 4.38∗ |
| Granulocytes (%) | 0.86 ± 0.17 | 0.34 ± 0.04 | 1.31 ± 0.13∗∗ | 1.5 ± 0.19∗∗∗ | 0.53 ± 0.16 | 1.3 ± 0.23∗∗ |
| RBC (×103 µL−1) | 8.16 ± 0.69 | 5.82 ± 0.50 | 7.58 ± 0.34 | 7.85 ± 1.64 | 3.96 ± 0.77 | 6.41 ± 0.99 |
| Hematocrite (%) | 46.1 ± 3.18 | 30.75 ± 3.68 | 38.86 ± 4.19 | 36.7 ± 3.94 | 26.26 ± 4.73 | 36.08 ± 3.71 |
| MCV (fL) | 57.41 ± 2.33 | 59.96 ± 2.610 | 56.28 ± 0.95 | 65.41 ± 3.01 | 68.45 ± 4.18 | 59.9 ± 1.50 |
| Platelets(×103 µL−1) | 574.57 ± 34.38 | 461.8 ± 50.09 | 614.93 ± 18.46 | 423.4 ± 122.32 | 449.33 ± 77.48 | 479.8 ± 56.15 |
| MCH (pg) | 18.62 ± 1.59 | 16.06 ± 0.58 | 17.51 ± 0.36 | 23.61 ± 7.23 | 16.61 ± 0.48 | 17.86 ± 1.01 |
| Hemoglobin (g/dL) | 14.64 ± 0.71 | 9.31 ± 1.13## | 12.06 ± 1.31 | 10.68 ± 0.93 | 5.5 ± 0.96 | 11.03 ± 1.55 |
| MCHC (g/dL) | 32.17 ± 1.25 | 27.23 ± 1.15## | 31.18 ± 0.67∗ | 27.18 ± 0.93 | 24.61 ± 0.92 | 27.31 ± 1.03 |
| IG (%) | 0.12 ± 0.04 | 0.6 ± 0.23 | 0.32 ± 0.11 | 1.03 ± 0.30 | 0.9 ± 0.27 | 0.15 ± 0.06 |
NOR = Animals serving as normal control and receiving distilled water (vehicle); DMBA = Animals serving as negative control and receiving distilled water (vehicle); TAMOX + DMBA = Animals serving as positive control and receiving tamoxifen at a dose of 3.3 mg/kg; and H. sabdariffa + DMBA = Animals receiving H. sabdariffa calyxes extract at doses of 125, 250, and 500 mg/kg. All animals except those in the normal group (NOR) were exposed to a single dose of DMBA (50 mg/kg; s.c.). #p < 0.05, ##p < 0.01; ###p < 0.001 compared to the NOR group; ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 compared to the DMBA group.